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KMID : 0545119990090030368
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Journal of Microbiology and Biotechnology
1999 Volume.9 No. 3 p.368 ~ p.370
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Protective Effects of Bifidobacterium spp. on Experimental Colon Carcinogenesis with 1,2-Dimethylhydrazine
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Han, Myung Joo
Park, Hae Young/Kim, Dong Hyun
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Abstract
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The protective role of Bifidobacterium spp. (B. breve K-110, B. breve K-111, and B. infantis K-525) isolated from the fecal samples of healthy Koreans was investigated on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in mouse colon. In mice fed normal diet with DMH treatment, an average of 68.5 ACF/colon was formed, whereas in mice administered with B. breve K-110, B. breve K-111, and B. infantis K-525, the numbers of DMH-induced ACF decreased to 7.2, 10.9, and 6.6 ACF/ colon, respectively. The mean number of crypts/focus was not significantly altered. Fecal harmful enzymes, such as β-glucuronidase, tryptophanase, and urease, were effectively inhibited during the administration of these bifidobacteria to mice. These results suggest that bifidobacteria could prevent colon cancer.
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KEYWORD
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